Tactics
Betis head coach Manuel Pellegrini opted for his favoured 4-2-3-1 system in the first leg – a formation he has used in 43 of Real’s 44 games this season, including Sunday’s 1-0 win over Athletic Bilbao.
Absentees
Ragnar Ache remains sidelined with a torn muscle fibre in his thigh, while Eintracht boss Oliver Glasner will make a late decision on injured trio Danny da Costa, Jesper Lindström and Sebastian Rode.
Betis have recently been without Héctor Bellerin, Andrés Guardado, Álex Moreno and Christian Tello.
Head-to-head
Eintracht’s 2-1 first-leg win was the first ever meeting between the teams in European competition.
Statistics
The Eagles are unbeaten in their last seven matches against Spanish opposition, winning five and drawing two. Their most recent home game against a La Liga side ended in a 1-0 victory over Deportivo La Coruna in December 1993.
After winning the first leg of a European tie, Eintracht have progressed to the next round in each of their last nine attempts. The last time they failed to do so was against FC Sochaux in the 1980/81 UEFA Cup, when they won the first leg 4-2 but were knocked out on away goals following a 2-0 second-leg defeat.