Bo Svensson kicked off the second half of the season alternating between a 3-1-4-2 and a 3-4-1-2 formation, but lately the Dane has preferred an attacking 3-5-2 or just one man up front in a 3-4-2-1.
Oliver Glasner will have to do without Martin Hinteregger, whose season came to a premature end after he went down with a hamstring injury in the second leg against West Ham. It remains to be seen whether Jesper Lindström, Rafael Santos Borré and Tuta, who are all returning to fitness, will be part of the squad.
For the hosts, Delano Burgzorg is out as he is suffering from myocarditis.
Eintracht Frankfurt have faced 1. FSV Mainz 05 27 times in the Bundesliga to date. Mainz have won nine of them and the Eagles eight, with the other 10 matches ending in a draw.
In their last three Bundesliga meetings with Mainz, Eintracht have picked up seven points with two wins and a draw.
The Eagles have won on the final day of the season for two years running – as many times as in their previous 14 top-flight campaigns.
Mainz have picked up 34 points at home so far in 2021/22 – 23 more than on their travels (11).
Makoto Hasebe is set to make his 358th Bundesliga appearance – a feat that will see the Japanese overtake Brazilian centre-back Naldo as the foreign player with the third most games in the German top flight.